Investigating the Connection Between Breast Cancer and Mammographic Breast Density

The Division of Cancer Epidemiology and Genetics at the National Cancer Institute has developed a research program to learn more about one of the stronger risk factors for breast cancer, mammographic breast density (MBD). Investigators have worked to use technology and methods to improve the measurement of density, outline risk factors that impact density, and learn about mechanisms that mediate the relationship between density and breast cancer risk. While it is known that MBD is a strong independent risk factor for breast cancer, it is still unknown what the mechanisms are that are driving that relationship. It has been recognized as well that MBD may also be a critical consideration in women who already have been diagnosed with breast cancer. Developing evidence suggests that decline in MBD may be a potential biosensor of response to tamoxifen therapy. Further research is needed to examine key issues in breast cancer, including MBD.

Reference:

Fisher V. Exploring the Relationship Between Mammographic Breast Density and Breast Cancer. National Cancer Institute. Published 2017. Accessed April 27, 2022. https://dceg.cancer.gov/printout-breast-density.pdf

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